Abstract: Adsorption thermodynamic functions for some organic solvent molecules on the surface of beta cyclodextrin(β-CD）have been measured using gas chromatographic technique.The experimental results confirm thatβ-CD molecule can form hostguest adduct with adsorbate molecule(guest) as it can in aqueous solution and show that when there is a strong intermolecular force between the host and the guest a type of synergistic interaction exists between,the inner cave and some hydroxyl groups of the CD molecule simultaneously with the apolar/hydrophobic and the polar/hydrophilic parts of the guest molecule.The experimental results also show that a phenomenon of mutual compensation between enthalpy and entropy relates closely with molecular recognize and the sum of the absolute values of adsorption enthalpy and entropy could be considered as a criterion to differentiate intermolecular force of the recognize.

Key words: Molecular recognize, Beta cyclodextrin, Enthalpy, Entropy, Criterion