Acta Phys. -Chim. Sin. ›› 2017, Vol. 33 ›› Issue (8): 1520-1532.doi: 10.3866/PKU.WHXB201704271

• REVIEW • Previous Articles     Next Articles

Application of Structural DNA Nanotechnology

Hong-Zhi ZHANG,Zhi-Qing ZHANG*(),Fang WANG,Ting ZHOU,Xiu-Feng WANG,Guo-Dong ZHANG,Ting-Ting LIU,Shu-Zhen LIU   

  • Received:2017-02-16 Published:2017-06-14
  • Contact: Zhi-Qing ZHANG
  • Supported by:
    the Scientific Research Foundation for Returned Overseas Chinese Scholars, China(2014010615);National Natural Science Foundation of China(21603276);National Natural Science Foundation of China(21303267);Natural Science Foundation of Shandong Province, China(ZR2016BL14);Fundamental Research Funds for the Central Universities, China(15CX05027A);Fundamental Research Funds for the Central Universities, China(16CX05013A)


DNA possesses extraordinary molecular recognition properties and remarkable structural features in the nano-level material regulation fields, which have shown enormous applications in many areas. In this review, we focus on DNA nanotechnology, including aspects ranging from modular DNA self-assembly to DNA origami, in addition to the recently reported novel assembly methods. Moreover, we summarize some applications of DNA nanotechnology, such as DNA-directed nanoparticle spatial positioning and orientation, and well-defined assembly of proteins on the DNA structure, as well as its uses, such as in the biomedical field, etc. The development and potential applications of DNA nanotechnology are also discussed.

Key words: DNA nanotechnology, Self-assembly, DNA module, DNA origami, Targeted drug delivery