物理化学学报 >> 1997, Vol. 13 >> Issue (06): 503-509.doi: 10.3866/PKU.WHXB19970606

研究论文 上一篇    下一篇

线粒体体外代谢热动力学模型及其演化优化研究

熊亚,潘正君,王宏,吴鼎泉,康立山,屈松生   

  1. 武汉大学化学系，武汉大学软件工程国家重点实验室，武汉 430072
  • 收稿日期:1996-09-22 修回日期:1996-11-25 发布日期:1997-06-15
  • 通讯作者: 屈松生

Studies on the Thermokinetic Model of Mitochondrial Metabolism and its Evolutionary Optimization

Xiong Ya,Pan Zheng-Jun,Wang Hong,Wu Ding-Quan,Kang Li-Shan,Qu Song-Sheng   

  1. Department of Chemistry,State Key Laboratory of Soft Engineer,Wuhan University,Wuhan 430072
  • Received:1996-09-22 Revised:1996-11-25 Published:1997-06-15
  • Contact: Qu Song-Sheng

PDF

2515

赞

摘要：

导出了线粒体体外代谢的热动力学方程（MTD）；探讨了它和指数模型的关系将演化计算技术引入生物热化学领域，用MTD方程和演化计算技术，对文献报导的八种鱼肝线粒体体外代谢的热动力学参数进行了全局优化.

关键词: 线粒体, 演化计算, 热动力学, 全局优化, 微量热

Abstract:

The thermokinetic equation (MTD) of mitochondrial metabolism was deduced and the relation between this equation and exponential model was examined. The technology of evolutionary computation was first introduced to the research  of biological thermochemistry. The thermokinetic parameters of some mitochondrial external metabolism were globally optimized with the evolutionary computation program about MTD, which was programmed ourselves, and excellent result was obtained.

Key words: Mitochondria, Evolution computation, Thermokinetics, Global optimum, Microcalorimetry