物理化学学报 >> 2025, Vol. 41 >> Issue (9): 100109.doi: 10.1016/j.actphy.2025.100109

所属专题： 碳点功能材料

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合理组装不同表面功能化碳点以增强近红外肿瘤光热治疗效果

吴雪1,†, 刘钰鹏1,†, 王冰哲1,2, 李凌云1, 黎镇坚1, 王青城1, 程全胜1, 刑贵川1, 曲松楠1,*()   

  1. 1 澳门大学应用物理及材料工程研究院(IAPME), 教育部联合重点实验室, 氹仔 999078, 澳门特别行政区
    2 暨南大学化学与材料科学学院, 广东省超分子配位化学重点实验室, 广东 广州 510632
  • 收稿日期:2025-04-29 修回日期:2025-05-23 录用日期:2025-05-29 发布日期:2025-07-04
  • 通讯作者: Email: songnanqu@um.edu.mo (曲松楠)
  • 作者简介:

    †These authors contributed equally to this work

  • 基金资助:
    澳门特别行政区科学技术发展基金(0139/2022/A3); 澳门特别行政区科学技术发展基金(0002/2024/TFP); 澳门特别行政区科学技术发展基金(0007/2021/AKP); 澳门大学—何鸿燊博士医疗拓展基金会“扬帆起航·共创未来”2025年度资助(SHMDF-OIRFS/2025/001); 国家自然科学基金(62205384)

Rationally assembling different surface functionalized carbon dots for enhanced near-infrared tumor photothermal therapy

Xue Wu1, Yupeng Liu1, Bingzhe Wang1,2, Lingyun Li1, Zhenjian Li1, Qingcheng Wang1, Quansheng Cheng1, Guichuan Xing1, Songnan Qu1,*()   

  1. 1 Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering (IAPME), University of Macau, Taipa 999078, Macau SAR, China
    2 College of Chemistry and Materials Science, and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry, Jinan University, Guangzhou 510632, Guangdong Province, China
  • Received:2025-04-29 Revised:2025-05-23 Accepted:2025-05-29 Published:2025-07-04
  • Contact: Email: songnanqu@um.edu.mo (Songnan Qu)
  • Supported by:
    the Science and Technology Development Fund of Macau SAR(0139/2022/A3); the Science and Technology Development Fund of Macau SAR(0002/2024/TFP); the Science and Technology Development Fund of Macau SAR(0007/2021/AKP); the University of Macau – Dr. Stanley Ho Medical Development Foundation "Set Sail for New Horizons, Create the Future" Grant 2025(SHMDF-OIRFS/2025/001); the National Natural Science Foundation of China(62205384)

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摘要：

碳点(CDs)因其优异的生物相容性和可调的光学特性，已成为近红外(NIR)介导的肿瘤治疗中极具前景的光热剂。然而，如何精确控制其组装行为以增强NIR吸收和光热转换效率仍不明确。在这项工作中，我们提出了一种因电子供体/受体复合而超组装的碳点(S-d/a-CDs)，通过将供电子碳点(d-CDs)与吸电子碳点(a-CDs)整合构建而成。这种复合的超碳点显著增强了S-d/a-CDs的NIR吸收能力。在740 nm激光照射下，S-d/a-CDs实现了65.8%的显著光热转换效率(PTCE)。S-d/a-CDs通过静脉注射表现出可忽略的细胞毒性和有效的肿瘤积累能力，能够在NIR激光照射后完全消除肿瘤。据我们所知，本研究首次利用两种CDs的协同组装进行光物理特性工程，为开发先进的NIR触发光热材料建立了开创性的范式。

关键词: 碳点, 光热疗法, 氢键, 组装, 电子供体/受体

Abstract:

Carbon dots (CDs) have emerged as promising photothermal agents for near-infrared (NIR)-mediated tumor therapy due to their excellent biocompatibility and tunable optical properties. However, it is still unclear how to precisely control their assembly behavior to enhance NIR absorption and photothermal conversion efficiency. In this work, we present a hyper-assembled electron donor/acceptor CDs complex (S-d/a-CDs), constructed by integrating electron-donating CDs (d-CDs) with electron-withdrawing CDs (a-CDs). This configuration significantly enhances the NIR absorption capacity of S-d/a-CDs. Under 740 nm laser irradiation, S-d/a-CDs achieve a remarkable photothermal conversion efficiency (PTCE) of 65.8%. S-d/a-CDs exhibit negligible cytotoxicity and effective tumor accumulation capacity through intravenous administration, enabling complete tumor elimination after NIR laser irradiation. To our knowledge, this study is the first to exploit synergistic assembles of two types of CDs for photo-physical property engineering, establishing a groundbreaking paradigm for the development of advanced NIR-triggered photothermal materials.

Key words: Carbon dots, Photothermal therapy, Hydrogen bond, Assemble, Donor/acceptor