抗抑郁化合物SIPI5358与环糊精形成的非共价复合物

doi:10.3866/PKU.WHXB20100911

Abstract

Abstract:

Non-covalent complexes of α-, β-, and γ-cyclodextrin (CD) with the antidepressant compound SIPI5358 were investigated by electrospray ionization mass spectrometry (ESI-MS), tandem mass spectrometry (MS/MS), UV spectroscopy, and fluorescence spectroscopy. The ESI-MS experimental results revealed that SIPI5358 reacted with the α-, β-, and γ-CD to form complexes with different coordination numbers. The tandem mass spectra further confirmed the formation of non-covalent complexes of SIPI5358 with β-CD. Binding of the complexes was also confirmed by UV as well as fluorescence spectra. The formation constant K_f was determined by fluorescence spectroscopy to be 3.45 ×10³mol·L^-1for the complex of SIPI5358 and β-CD.

Key words: Cyclodextrin, Antidepressant, Non-covalent complex, UV spectroscopy, Electrospray ionization mass spectrometry, Fluorescence spectroscopy

HE Xiao-Dan, JIANG Dan, CHEN Chen, CHU Yan-Qiu, DING Chuan-Fan, WENG Zhi-Jie, LI Jian-Qi. Non-Covalent Complexes of the Antidepressant Compound SIPI5358 with Cyclodextrins[J].Acta Phys. -Chim. Sin., 2010, 26(10): 2604-2612.

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Non-Covalent Complexes of the Antidepressant Compound SIPI5358 with Cyclodextrins

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