双孔道管状有序介孔炭对维生素B12的吸附缓释性能

doi:10.3866/PKU.WHXB20110834

Abstract

Abstract: Ordered mesoporous carbon with hexagonal arrays consisting of tubular-type pores (CMK-5) was synthesized via a nanocasting process by the direct use of SBA-15 as a template, furfuryl alcohol as a carbon source and oxalic acid as the catalyst. The structure of CMK-5 was analyzed by different techniques including scanning electron microscopy, powder X-ray diffraction and N₂ adsorption analysis. The specific surface area and pore volume were found to be 1856 m²·g^-1 and 2.10 cm³·g^-1, respectively, with mesopore sizes concentrated at 3.1 and 5.5 nm. Because of the unique structure the adsorption capacities of CMK-5 towards vitamin B12 was found to be as high as 943 mg·g^-1 in a short period of 120 min, which is significantly higher than that of commercial activated carbon. The composites of CMK-5 and vitamin B12 without any treatment gave slow-release performance in a simulated body fluid. The concentration of the release solutions remained 9 mg·L^-1 under dynamic conditions. A high loading capacity and slow release rate of vitamin B12 on the CMK-5 support suggested that CMK-5 might have a potential application in drug delivery.

Key words: Ordered mesoporous carbon, Dual-model pore channel, Vitamin B12, Adsorption, Drug release

WANG Xiao-Rong, HAO Guang-Ping, LU An-Hui, LI Wen-Cui. Adsorption and Release Behavior of Vitamin B12 in Tubular Structured Ordered Mesoporous Carbon[J].Acta Phys. -Chim. Sin., 2011, 27(09): 2239-2243.

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Adsorption and Release Behavior of Vitamin B12 in Tubular Structured Ordered Mesoporous Carbon

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