Acta Phys. -Chim. Sin. ›› 2011, Vol. 27 ›› Issue (09): 2239-2243.doi: 10.3866/PKU.WHXB20110834

• PHYSICAL CHEMISTRY OF MATERIALS • Previous Articles     Next Articles

Adsorption and Release Behavior of Vitamin B12 in Tubular Structured Ordered Mesoporous Carbon

WANG Xiao-Rong, HAO Guang-Ping, LU An-Hui, LI Wen-Cui   

  1. State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116023, Liaoning Province, P. R. China
  • Received:2011-04-18 Revised:2011-06-14 Published:2011-08-26
  • Contact: LI Wen-Cui
  • Supported by:

    The project was supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (20100041110017).

Abstract: Ordered mesoporous carbon with hexagonal arrays consisting of tubular-type pores (CMK-5) was synthesized via a nanocasting process by the direct use of SBA-15 as a template, furfuryl alcohol as a carbon source and oxalic acid as the catalyst. The structure of CMK-5 was analyzed by different techniques including scanning electron microscopy, powder X-ray diffraction and N2 adsorption analysis. The specific surface area and pore volume were found to be 1856 m2·g-1 and 2.10 cm3·g-1, respectively, with mesopore sizes concentrated at 3.1 and 5.5 nm. Because of the unique structure the adsorption capacities of CMK-5 towards vitamin B12 was found to be as high as 943 mg·g-1 in a short period of 120 min, which is significantly higher than that of commercial activated carbon. The composites of CMK-5 and vitamin B12 without any treatment gave slow-release performance in a simulated body fluid. The concentration of the release solutions remained 9 mg·L-1 under dynamic conditions. A high loading capacity and slow release rate of vitamin B12 on the CMK-5 support suggested that CMK-5 might have a potential application in drug delivery.

Key words: Ordered mesoporous carbon, Dual-model pore channel, Vitamin B12, Adsorption, Drug release