物理化学学报 >> 2026, Vol. 42 >> Issue (10): 100265.doi: 10.1016/j.actphy.2026.100265

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透明亲水的“凤凰衣”用作角膜修复材料

李翊萌1,†, 杨元元2,†, 王征科1,2,*()   

  1. 1 教育部高分子合成与功能构造重点实验室, 浙江大学高分子科学与工程学系, 浙江 杭州 310058
    2 浙江大学医学院附属第二医院, 浙江 杭州 310009
  • 收稿日期:2025-12-07 修回日期:2026-02-14 录用日期:2026-02-25 发布日期:2026-09-03
  • 通讯作者: Email: wangzk@zju.edu.cn (王征科)
  • 作者简介:

    †这些作者对这项工作做出了同等贡献

Transparent and hydrophilic "phoenix garment" for corneal stromal regeneration

Yimeng Li1,†, Yuanyuan Yang2,†, Zhengke Wang1,2,*()   

  1. 1 MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, Zhejiang Province, China
    2 The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
  • Received:2025-12-07 Revised:2026-02-14 Accepted:2026-02-25 Published:2026-09-03
  • Contact: Email: wangzk@zju.edu.cn (Zhengke Wang)

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摘要：

全球范围内，由角膜瘢痕、基质缺损及创伤导致的不可逆性失明病例数目持续攀升。供体角膜短缺、羊膜及胶原补片的高昂成本及复杂的伦理问题，使得开发一种来源丰富、低成本，且可规模化生产的替代方案成为迫切临床需求。本研究提出“碱化透明”处理方案，使“凤凰衣”(鸡蛋壳膜，ESM)表现出透明性、亲水性及高饱和水含量，同时保留其柔韧性和耐缝合性，且在生理环境的降解速率与组织修复同步。在新西兰大白兔角膜前板层缺损模型中，补片与宿主基质快速整合，一周内实现完全上皮化，八周内角膜表面恢复光滑透明，胶原排列整齐且无瘢痕形成，表明其有效抑制了肌成纤维细胞活化，并重建了上皮屏障。ESM具有来源广泛、制备简便、可室温储存等优势，为角膜基质替代提供了一种安全、经济且具临床转化潜力的新策略。

关键词: 凤凰衣, 蛋壳膜, 碱处理, 角膜再生, 生物材料

Abstract:

Globally, irreversible blindness caused by corneal scarring, stromal defects, and trauma continues to rise. Shortages of donor corneas, the high cost of amniotic membrane and collagen patches, and complex ethical oversight have made the development of an abundant, low-cost, and scalable alternative a pressing clinical need. Herein, an "alkaline-transparency" protocol was developed to render "phoenix garment" (chicken eggshell membrane, ESM), transparent, hydrophilicity, and high saturated water content, while preserving its flexibility and suture compatibility. The membrane gradually degraded in the physiological environment, adapting to the pace of tissue repair. In a rabbit anterior-lamellar defect model, the patch rapidly integrated with host stroma, achieving complete re-epithelialization within one week and restoring a smooth, transparent corneal surface within eight weeks, with neatly aligned collagen and no scar formation, indicating effective suppression of myofibroblast activation and reliable restoration of the epithelial barrier. ESM is abundantly available, easy to prepare, and storable at room temperature, offering a safe, economical, and clinically translatable strategy for corneal stromal replacement.

Key words: Phoenix garment, Eggshell membrane, Alkaline treatment, Corneal regeneration, Biomaterials