物理化学学报 >> 2018, Vol. 34 >> Issue (12): 1321-1333.doi: 10.3866/PKU.WHXB201802081

所属专题: 表面物理化学

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  • 收稿日期:2018-01-09 发布日期:2018-04-27
  • 通讯作者: 许维 E-mail:xuwei@tongji.edu.cn
  • 作者简介:许维教授,出生于1981年。2008年在丹麦奥胡斯大学物理系获得理学博士学位,随后在美国宾夕法尼亚州立大学物理系从事博士后研究。2009年被聘为同济大学特聘教授加盟材料科学与工程学院,同时担任丹麦奥胡斯大学交叉学科纳米中心客座教授。主要从事利用超高真空扫描隧道显微镜(UHV-STM)高分辨成像及单分子操纵技术并结合密度泛函理论(DFT)计算研究固体表面物理化学相关课题
  • 基金资助:

Interactions between Bases and Metals on Au(111) under Ultrahigh Vacuum Conditions

Xinyi WANG,Lei XIE,Yuanqi DING,Xinyi YAO,Chi ZHANG,Huihui KONG,Likun WANG,Wei XU*()   

  • Received:2018-01-09 Published:2018-04-27
  • Contact: Wei XU E-mail:xuwei@tongji.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(21473123);the National Natural Science Foundation of China(21622307)



关键词: 碱基, 金属, 静电作用, 配位作用, 扫描隧道显微镜, 密度泛函理论计算


Nucleobases (guanine (G), adenine (A), thymine (T), cytosine (C), and uracil (U)) are important constituents of nucleic acids, which carry genetic information in all living organisms, and play vital roles in structure formation, functionalization, and biological catalytic processes. The principle of complementary base pairing is significant in the high-fidelity replication of DNA and RNA. In addition to their specific recognition, the interaction between bases and other reactants, such as metals, salts, and certain small molecules, may cause distinct effects. Specifically, the interactions between bases and certain metal atoms or ions could damage nucleic acids, inducing gene mutation and even carcinogenesis. In the meantime, nanoscale devices based on metal-DNA interactions have become the focus of research in nanotechnology. Therefore, extensive researches on the interactions between metals and bases and the corresponding mechanism are of great importance and may make improvements in the fields of both biochemistry and nanotechnology. Scanning tunneling microscopy (STM) is a powerful tool for effectively resolving nanostructures in real space and on the atomic scale under ultrahigh vacuum (UHV) conditions. Moreover, density functional theory (DFT) calculations could help elucidate the reaction pathways and their mechanisms. In this review, we summarize the distinct interactions between bases (including their derivatives) and various metal species (comprising alkali, alkaline earth, and transition metals) derived from metal sources and the corresponding salts on the Au(111) substrate reported recently based on the results obtained by a combination of above two methods. In general, bases afford N and/or O binding sites to interact with metal atoms, resulting in various motifs via coordination or electrostatic interactions, and form intermolecular hydrogen bonds to stabilize the whole system. On the basis of high-resolution STM images and DFT calculations, structural models and the possible reaction pathways are proposed, and their underlying mechanisms, which reveal the nature of the interactions, are thus obtained. Among them, we summarize the construction of G-quartet structures with different kinds of central metals like Na, K, and Ca, which are directly introduced by salts, and their relative stabilities are compared. In addition, salts can provide not only metal cations but also halogen anions in modulating the structure formation with bases. The halogen species enable the regulation of metal-organic motifs and induce phase transition by locating at specific hydrogen-rich sites. Moreover, reversible structural transformations of metal-organic nanostructures are realized owing to the intrinsic dynamic characteristic of coordination bonds, together with the coordination priority and diversity. Furthermore, the controllable scission and seamless stitching of metal-organic clusters, which contain two types of hierarchical interactions, have been successfully achieved through STM manipulations. Finally, this review offers a thorough comprehension on the interaction between bases and metals on Au(111) and provide fundamental insights into controllable fabrication of nanostructures of DNA bases. We also admit the limitation involved in detecting biological processes by on-surface model system, and speculate on future studies that would use more complicated biomolecules together with other technologies.

Key words: Bases, Metal, Electrostatic interaction, Coordination interaction, Scanning tunneling microscopy, Density functional theory calculation