铂单原子功能化的二维Al-TCPP金属-有机框架纳米片用于增强光动力抗菌治疗

doi:10.1016/j.actphy.2025.100046

物理化学学报 >> 2025, Vol. 41 >> Issue (5): 100046.doi: 10.1016/j.actphy.2025.100046

铂单原子功能化的二维Al-TCPP金属-有机框架纳米片用于增强光动力抗菌治疗

何世央¹^,²^,†, 储丹丹³^,†, 庞志鑫¹, 杜雨航¹, 王嘉怡¹, 陈雨鸿¹, 苏雨蒙¹, 秦建华¹, 潘湘蓉¹, 周战¹^,*(), 李景果³^,*(), 马录芳¹^,²^,*(), 谭超良⁴^,⁵^,*()

¹ 洛阳师范学院化学化工学院, 河南省功能导向多孔材料重点实验室, 河南洛阳 471934
² 郑州大学化学学院, 郑州 450001
³ 河南省人民医院, 郑州大学人民医院, 郑州 450003
⁴ 香港大学电机电子工程系, 香港 999077
⁵ 香港城市大学电机工程系, 香港 999077

收稿日期:2024-08-06 修回日期:2024-09-18 录用日期:2024-09-20 发布日期:2025-04-18
通讯作者: Email: zhouzhan@lynu.edu.cn (周战)lijingguo@zzu.edu.cn (李景果)mazhuxp@126.com (马录芳)cltan@hku.hk; chaoltan@cityu.edu.hk; Tel.: +852-34429405 (谭超良)
作者简介:
^†These authors contributed equally to this work.
基金资助:
国家自然科学基金(52102348); 国家自然科学基金(22271130); 国家自然科学基金(52173143); 河南省高校科技创新人才(23HASTIT016); 河南省自然科学基金(242300421018); 谭超良感谢国家优秀青年科学基金(港澳)(52122002)

Pt Single-Atom-Functionalized 2D Al-TCPP MOF Nanosheets for Enhanced Photodynamic Antimicrobial Therapy

Shiyang He¹^,², Dandan Chu³, Zhixin Pang¹, Yuhang Du¹, Jiayi Wang¹, Yuhong Chen¹, Yumeng Su¹, Jianhua Qin¹, Xiangrong Pan¹, Zhan Zhou¹^,*(), Jingguo Li³^,*(), Lufang Ma¹^,²^,*(), Chaoliang Tan⁴^,⁵^,*()

¹ College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, Henan Province, China
² College of Chemistry, Zhengzhou University, Zhengzhou 450001, China
³ Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China
⁴ Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR 999077, China
⁵ Department of Electrical Engineering, City University of Hong Kong, Hong Kong SAR 999077, China

Received:2024-08-06 Revised:2024-09-18 Accepted:2024-09-20 Published:2025-04-18
Contact: Email: zhouzhan@lynu.edu.cn (Zhan Zhou)lijingguo@zzu.edu.cn (Jingguo Li)mazhuxp@126.com (Lufang Ma)cltan@hku.hk; chaoltan@cityu.edu.hk; Tel.: +852-34429405 (Chaoliang Tan)
Supported by:
the National Natural Science Foundation of China(52102348); the National Natural Science Foundation of China(22271130); the National Natural Science Foundation of China(52173143); the Science and Technology Innovation Talent Program of University in Henan Province(23HASTIT016); the Natural Science Foundation of Henan Province of China(242300421018); C.T. thanks the funding support from the National Natural Science Foundation of China - Excellent Young Scientists Fund (Hong Kong and Macau)(52122002)

1. WHXB202408006-SI-7p.pdf(3434KB)

摘要/Abstract

摘要：

面对由病原微生物感染引发疾病所带来的紧迫挑战，开发新型且高效的抗菌策略已成为当务之急。尽管光动力治疗在抗菌治疗领域已得到广泛应用，但在精确调控光敏剂结构以实现高效光动力性能方面仍存在一定的挑战。本文中，我们将铂单原子(SAs)锚定在二维(2D) Al-TCPP金属-有机框架(Pt/Al-TCPP)纳米片上，并将其用作光敏剂增强活性氧(ROS)的产生，实现高效的光动力抗菌治疗。通过将Pt SAs锚定到2D Al-TCPP纳米片上，我们不仅改善了Pt SAs的分散性和稳定性，还利用了MOF晶体多孔结构与Pt SAs之间的协同作用，优化了光子功能和光捕获能力。这种结构增强了Pt SAs与卟啉连接体之间的桥接单元，促进了光照下的高效电荷转移和分离，从而增强ROS的产生。同时，除了Pt SAs的固有光动力性能之外，它的存在还能增加氧气的吸附、加速电子转移、促进电荷分离，从而提高其光动力产生ROS的效率。因此，与Al-TCPP相比，Pt/Al-TCPP光敏剂在660 nm激光照射下显示出更高的ROS生成效率。体外和体内实验均表明，在激光照射下，较低剂量的Pt/Al-TCPP纳米片能够在较短时间内有效杀灭细菌并促进伤口愈合。本研究结果为抗菌策略的开发提供了新视角，并展示了Pt/Al-TCPP纳米片作为高效伤口愈合治疗剂的潜力。

关键词: 铂单原子, 二维金属-有机框架材料, 光动力治疗, 抗菌, 伤口愈合

Abstract:

The pressing challenges posed by infectious diseases caused by pathogenic microbial infections have necessitated the development of advanced antimicrobial strategies. Among the promising avenues, photodynamic therapy (PDT) has emerged as a promising approach due to its non-invasive and targeted nature. Although it has been widely used in antibacterial therapy, there are still obstacles in precisely regulating the structure of photosensitizers to achieve satisfactory photodynamic performance. Herein, Pt single-atoms (SAs) are deposited on two-dimensional (2D) Al-TCPP metal-organic framework (MOF) nanosheets, creating Pt/Al-TCPP as the photosensitizer to boost reactive oxygen species (ROS) production for enhanced photodynamic antimicrobial therapy. By integrating Pt SAs onto 2D Al-TCPP MOF nanosheets, we not only improve the dispersion and stability of Pt atoms but also harness the synergistic effect between the MOF's crystal porous structure and Pt SAs, optimizing its light-trapping ability. This unique structure enhances the bridging unit between Pt SA and the porphyrin linker, facilitating efficient charge transfer and separation during illumination, ultimately boosting ROS production. In addition to the inherent photodynamic performance of Pt SAs, they can also increase the adsorption of oxygen, facilitate electron transfer, and improve charge separation, thus enhancing photodynamic ROS generation efficiency. Therefore, the Pt/Al-TCPP photosensitizer shows much greater efficacy in generating ROS under a 660 nm laser irradiation compared to Al-TCPP. Both in vitro and in vivo experiments demonstrate that the Pt/Al-TCPP nanosheets can effectively eliminate bacteria and promote wound healing in a short time at low doses under laser irradiation. This study underscores the advantages of integrating Pt SAs with Pt/Al-TCPP nanosheets and offers a highly effective photosensitizer for bacterial infections. The results pave the way for novel strategies in the antibacterial realm, highlighting the potential of Pt/Al-TCPP nanosheets as a promising therapeutic agent for efficient wound healing.

Key words: Pt single-atoms, 2D MOFs, Photodynamic therapy, Antimicrobial, Wound healing

何世央, 储丹丹, 庞志鑫, 杜雨航, 王嘉怡, 陈雨鸿, 苏雨蒙, 秦建华, 潘湘蓉, 周战, 李景果, 马录芳, 谭超良. 铂单原子功能化的二维Al-TCPP金属-有机框架纳米片用于增强光动力抗菌治疗[J]. 物理化学学报, 2025, 41(5), 100046. doi: 10.1016/j.actphy.2025.100046

Shiyang He, Dandan Chu, Zhixin Pang, Yuhang Du, Jiayi Wang, Yuhong Chen, Yumeng Su, Jianhua Qin, Xiangrong Pan, Zhan Zhou, Jingguo Li, Lufang Ma, Chaoliang Tan. Pt Single-Atom-Functionalized 2D Al-TCPP MOF Nanosheets for Enhanced Photodynamic Antimicrobial Therapy[J]. Acta Phys. -Chim. Sin. 2025, 41(5), 100046. doi: 10.1016/j.actphy.2025.100046

链接本文: https://www.whxb.pku.edu.cn/CN/10.1016/j.actphy.2025.100046

https://www.whxb.pku.edu.cn/CN/Y2025/V41/I5/100046

图/表 4

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铂单原子功能化的二维Al-TCPP金属-有机框架纳米片用于增强光动力抗菌治疗

Pt Single-Atom-Functionalized 2D Al-TCPP MOF Nanosheets for Enhanced Photodynamic Antimicrobial Therapy

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