Acta Phys. -Chim. Sin. ›› 2014, Vol. 30 ›› Issue (11): 2085-2091.doi: 10.3866/PKU.WHXB201409051

• ELECTROCHEMISTRY AND NEW ENERGY • Previous Articles     Next Articles

Preparation and Electrochemical Properties of Phenobarbital Molecularly Imprinted Polymer Sensor Based on a CuO Nanoparticle-Modified Glassy Carbon Electrode

YU Hui-Cheng1, HUANG Xue-Yi1, LI Hao1, LEI Fu-Hou1, TAN Xue-Cai1, WEI Yi-Chun1, WU Hai-Ying2   

  1. 1. Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, P. R. China;
    2. Guangzhou Research Institute of Nonferrous Metals, Guangzhou 510651, P. R. China
  • Received:2014-06-05 Revised:2014-09-05 Published:2014-10-30
  • Contact: YU Hui-Cheng, TAN Xue-Cai E-mail:doyhc@126.com;tanxc118@163.com
  • Supported by:

    The project was supported by the Project of the Education Department of Guangxi, China (2013YB068), National Natural Science Foundation of China (21365004), Guangxi Natural Science Key Foundation, China (2013GXNSFDA019006), High-Level-Innovation Team and Outstanding Scholar Project of Guangxi Higher Education Institutes, China (guijiaoren[2014]7), and Innovation Project of Guangxi Graduate Education, China (gxun-chx2014120).

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Abstract:

To improve the sensitivity of molecular imprinted electrochemical sensors, a molecularly imprinted polymer (MIP) film for the determination of phenobarbital (PB) was electropolymerized on a CuO nanoparticlemodified glassy carbon electrode. Methacrylic acid was used as the functional monomer and ethylene glycol maleic rosinate acrylate as a cross-linking agent in the presence of supporting electrolyte (tetrabutylammonium perchlorate). The electrochemical properties of CuO nanoparticle-modified molecularly imprinted and non-imprinted polymer (NIP) sensors were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The results showed that the electrochemical properties of the CuO nanoparticle-modified MIP sensor were completely different from those of NIP sensors. X-ray diffraction confirmed that the nanoparticles were CuO. The morphology of the CuO nanoparticle-modified MIP sensor was examined under a scanning electron microscope. The CuO nanoparticles were uniformly distributed on the surface of the modified glassy carbon electrode, which improved the recognition sites of the modified MIP sensor. The response value of the DPV peak current showed linear dependence on the PB concentration in the range 1.0×10-8 to 1.8×10-4 mol·L-1 (linear regression coefficient =0.9994) with a detection limit (S/N=3) of 2.3×10-9 mol·L-1. The results indicated that the CuO nanoparticle-modified MIP sensor is one of the most sensitive and selective sensors for PB determination. The prepared sensor was successfully applied for the determination of PB in practical samples and the recovery ranged from 95.0% to 102.5%.

Key words: CuO nanoparticle, Phenobarbital, Molecular imprinted polymer, Electropolymerization, Sensor