物理化学学报 >> 2006, Vol. 22 >> Issue (02): 226-229.doi: 10.3866/PKU.WHXB20060219

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超临界CO2法制备头孢唑啉钠脂质体

严宾; 安学勤; 白晶; 张英华   

  1. 南京师范大学化学与环境科学学院, 南京 210097
  • 收稿日期:2005-07-18 修回日期:2005-09-07 发布日期:2006-01-22
  • 通讯作者: 安学勤 E-mail:anxueqin@njnu.edu.cn

Preparation of Cefazolin Sodium Liposomes by Supercritical Carbon Dioxide Method

YAN Bin; AN Xue-qin; BAI Jing; ZHANG Ying-hua   

  1. College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, P. R. China
  • Received:2005-07-18 Revised:2005-09-07 Published:2006-01-22
  • Contact: AN Xue-qin E-mail:anxueqin@njnu.edu.cn

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摘要： 采用超临界CO2(scCO2)流体代替有机溶剂一步法制备了头孢唑啉钠药物载体脂质体. 研究了该脂质体的尺寸、稳定性和药物的包封率. 结果表明, 脂质体的尺寸和稳定性依赖于制备压力, 脂质体对头孢唑啉钠的包封率与乙醇和脂浓度有关, 采用超临界CO2法制备脂质体的药物包封率比采用薄膜分散法(Bangham method)制备的包封率高.

关键词: 脂质体, 头孢唑啉钠, 超临界CO2, 包封率, 粒径, 稳定性

Abstract: The liposomes of cefazolin sodium were prepared using one step supercritical CO2 (scCO2) method. The size, stability, and trapping efficiency of liposomes were investigated. The experimental results demonstrate that the size and stability of liposomes depend on the pressure. The trapping efficiency of liposomes relates to the concentration of ethanol and lipid. The trapping efficiency by the scCO2 method is much higher than the results from the Bangham method.

Key words: Liposomes, Cefazolin sodium, scCO2, Trapping efficiency, Particle size, Stability