物理化学学报 >> 2026, Vol. 42 >> Issue (7): 100223.doi: 10.1016/j.actphy.2025.100223

所属专题： 碳点功能材料

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石墨烯量子点介导的肖特基结光疗：卓越抗菌性能与快速伤口愈合

李江婷1,2,3,†, 欧阳峰1,3,4,†, 王强1,2,3,†, 周尚1,2,3, 包锡旭1,2,3, 程雅琪1,2,3, 杨一菲1,2,3, 陈沛1,2,3, 陈伊鹏1,3,4, 张继业5, 王亮6,*(), 钟海舰1,2,3,*()   

  1. 1 赣南医科大学组织工程江西省重点实验室, 江西 赣州 341000
    2 赣南医科大学医学信息工程学院, 江西 赣州 341000
    3 赣南医科大学心脑血管疾病防治教育部重点实验室, 江西 赣州 341000
    4 赣南医科大学基础医学院, 江西 赣州 341000
    5 上海大学材料科学与工程学院, 上海 200444
    6 上海大学环境与化学工程学院纳米化学与生物学研究所, 上海 200444
  • 收稿日期:2025-09-01 修回日期:2025-11-17 录用日期:2025-11-20 发布日期:2026-05-22
  • 通讯作者: Email: wangl@shu.edu.cn (王亮)Hjzhong2007@gmu.edu.cn (钟海舰)
  • 作者简介:

    †这些作者对这项工作做出了同等贡献

Schottky junction phototherapy mediated by graphene quantum dots for superior antibacterial performance and rapid wound healing

Jiangting Li1,2,3, Feng Ouyang1,3,4, Qiang Wang1,2,3, Shang Zhou1,2,3, Xixu Bao1,2,3, Yaqi Cheng1,2,3, Yifei Yang1,2,3, Pei Chen1,2,3, Yipeng Chen1,3,4, Jiye Zhang5, Liang Wang6,*(), Haijian Zhong1,2,3,*()   

  1. 1 Jiangxi Provincial Key Laboratory of Tissue Engineering, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
    2 School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
    3 Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
    4 School of Basic Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
    5 School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China
    6 Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China
  • Received:2025-09-01 Revised:2025-11-17 Accepted:2025-11-20 Published:2026-05-22
  • Contact: Email: wangl@shu.edu.cn (Liang Wang)Hjzhong2007@gmu.edu.cn (Haijian Zhong)

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摘要：

抗生素耐药性感染日益严重的威胁亟需发展先进的非侵入性治疗策略。本文构建了一种基于肖特基结的金纳米粒子(AuNPs)与氧化石墨烯量子点(GOQDs)纳米复合材料，其中GOQDs作为多功能构建单元，在460 nm LED照射下协同增强光动力治疗(PDT)和光热治疗(PTT)。GOQDs不仅能促进电荷分离与转移以产生活性氧(ROS)，其宽光谱吸收特性与高电子迁移率还可提升光热转换效率。此外，其丰富的表面官能团可增强分散性、生物相容性及组织亲和力。所制备的AuNPs/GOQDs纳米复合材料展现出优异的分散稳定性、增强的光热与ROS输出性能以及卓越的生物相容性。体外抗菌实验表明其对革兰氏阳性菌和阴性菌的杀灭效率均 > 97%。更重要的是，在小鼠伤口感染模型中，该纳米复合材料能在9天内实现约99%的伤口愈合率，显著优于对照组治疗。组织学分析进一步证实其能减轻炎症并加速组织再生。本研究揭示了GOQDs在增强光触发抗菌活性和促进伤口愈合中的关键作用，为临床治疗多重耐药病原体提供了有前景的光疗策略。

关键词: 氧化石墨烯量子点, 抗菌, 金纳米颗粒, 肖特基结, 联合光疗

Abstract:

The growing threat of antibiotic-resistant infections calls for advanced non-invasive therapeutic strategies. Herein, we construct a Schottky junction-based nanocomposite composed of gold nanoparticles (AuNPs) and graphene oxide quantum dots (GOQDs), where GOQDs serve as multifunctional building blocks to synergistically enhance both photodynamic therapy (PDT) and photothermal therapy (PTT) under 460 nm LED irradiation. GOQDs not only facilitate charge separation and transfer for reactive oxygen species (ROS) generation, but also improve photothermal conversion due to their broad optical absorption and high electron mobility. Moreover, their abundant surface functional groups enhance dispersion, biocompatibility, and tissue affinity. The as-prepared AuNPs/GOQDs nanocomposites exhibit excellent dispersion stability, enhanced photothermal and ROS output, and superior biocompatibility. In vitro antibacterial assays demonstrate > 97% bacterial eradication efficiency against both Gram-positive and Gram-negative bacteria. More importantly, in a murine wound infection model, the nanocomposite enables ~99% wound healing within 9 days, significantly outperforming control treatments. Histological analysis further confirms accelerated tissue regeneration with reduced inflammation. This study highlights the critical function of GOQDs in amplifying light-triggered antibacterial activity and accelerating wound healing, offering a promising strategy for clinical phototherapy against multidrug-resistant pathogens.

Key words: Graphene oxide quantum dots, Antibacterial, AuNPs, Schottky junction, Combined phototherapy