Triton X-100六角液晶相中制备镁铝层状双金属氢氧化物纳米片及其药物载体应用

doi:10.3866/PKU.WHXB201504021

Abstract

Abstract:

A hexagonal lyotropic liquid crystal (LLC) was constructed with nonionic surfactant Triton X-100 and mixed magnesium chloride/aluminum chloride aqueous solutions. Layered double hydroxide (LDH) nanosheets (L-LDHs) were prepared using the LLC as a microreactor. A nanohybrid material of L-LDHs intercalated with a model anionic drug, diclofenac sodium (DS; DS/L-LDHs) was synthesized using an ionexchange method. The drug-release profile of DS/L-LDH was investigated under moderate conditions, i.e., 37.0 ℃ and pH 7.2. The results were compared with those for common LDH flaky particles (S-LDHs) synthesized using a traditional solution coprecipitation method. The crystalline structures, specific surface areas, and morphologies of these LDHs and DS/LDHs nanohybrids were characterized using powder X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and N₂ adsorption-desorption. The results show that the L-LDH JEparticles are less thick, and have larger specific surface areas and higher DS-loading capacities than the S-LDH particles. Drug release by the DS/L-LDH nanohybrid was clearly lower than that by the DS/S-LDH nanohybrid. This indicates that the L-LDH nanosheets are more suitable for use as drug carriers than the S-LDHs. Drug release by the DS/L-LDH nanohybrid can be described using a pesudo-second-order kinetic model, and drug diffusion through the LDH particles is the rate-limiting step. LLC can be used as a template for morphologycontrolled synthesis of LDHs.

Key words: Layered double hydroxide, Lyotropic liquid crystal, Triton X-100, Nanohybrid, Drug release

ZHAO Ji-Kuan, XIE Yan-Fang, XU Jie, HOU Wan-Guo. Preparation of Mg₂Al Layered Double Hydroxide Nanosheets from Triton X-100 Hexagonal Lyotropic Liquid Crystal and Their Application as Drug Carriers[J]. Acta Phys. -Chim. Sin. 2015, 31(6), 1199-1206. doi: 10.3866/PKU.WHXB201504021

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Preparation of Mg₂Al Layered Double Hydroxide Nanosheets from Triton X-100 Hexagonal Lyotropic Liquid Crystal and Their Application as Drug Carriers

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Preparation of Mg₂Al Layered Double Hydroxide Nanosheets from Triton X-100 Hexagonal Lyotropic Liquid Crystal and Their Application as Drug Carriers